miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation

Abstract Molecular mechanisms regulating preterm birth (PTB)-associated cervical remodeling remain unclear.Prior work demonstrated an altered miRNA profile, with significant increases in miR-143 and miR-145, in cervical cells of women destined to have a PTB.The study objective was to determine the effect of miR-143 and miR-145 on the cervical epith

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A living critical interpretive synthesis to yield a framework on the production and dissemination of living evidence syntheses for decision-making

Abstract Background The COVID-19 pandemic has had an unprecedented impact in the global research production and has also increased research waste.Living evidence syntheses (LESs) seek to regularly update a body of evidence addressing a specific question.During the COVID-19 pandemic, the production and dissemination of LESs emerged as a cornerstone

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